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Title: Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease
Authors: PENIDO, Alexandre Batista
MORAIS, Selene Maia de
RIBEIRO, Alan Bezerra
ALVES, Daniela Ribeiro
RODRIGUES, Ana Livya Moreira
SANTOS, Leonardo Hunaldo dos
MENEZES, Jane Eire Silva Alencar de
Keywords: Alzheimer’s disease
Issue Date: 2017
Publisher: HINDAWI
Citation: PENIDO, A. B. et al. Medicinal plants from Northeastern Brazil against Alzheimer's disease. Evidence-Based Complementary and Alternative Medicine, v. 2017, p. 1-7, 2017. Article ID 1753673. DOI:
Abstract: Alzheimer’s disease (AD) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes. In the northeast region of Brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for AChE inhibition evaluation. The phenolic compounds content was determined by Folin–Ciocalteu test and flavonoid content with AlCl3 reagent using UV-visible spectrophotometry. The antioxidant activity was assessed analyzing the inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS) and by the β-carotene/linoleic acid system and acetylcholinesterase inhibition using qualitative and quantitative tests. The combination of better acetylcholinesterase inhibitory and antioxidant activities pointed out six species, in descending order, as the best potential sources of therapeutic agents against AD: Hancornia speciosa > Myracrodruon urundeuva > Copaifera langsdorffii > Stryphnodendron coriaceum > Psidium guajava > Mangifera indica. Besides, the phenolic compounds in the species probably contribute to these activities. However, further pharmacological studies to assess the specific applications of these plants against AD are required to confirm these results.
ISSN: 1741-4288
Appears in Collections:Artigos - Enfermagem (CCSST)
Artigos - Engenharia de Alimentos

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