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dc.contributor.authorPENIDO, Alexandre Batista
dc.contributor.authorMORAIS, Selene Maia de
dc.contributor.authorRIBEIRO, Alan Bezerra
dc.contributor.authorALVES, Daniela Ribeiro
dc.contributor.authorRODRIGUES, Ana Livya Moreira
dc.contributor.authorSANTOS, Leonardo Hunaldo dos
dc.contributor.authorMENEZES, Jane Eire Silva Alencar de
dc.date.accessioned2018-04-26T19:11:33Z
dc.date.accessioned2018-04-26T19:20:49Z-
dc.date.available2018-04-26T19:11:33Z
dc.date.available2018-04-26T19:20:49Z-
dc.date.issued2017
dc.identifier.citationPENIDO, A. B. et al. Medicinal plants from Northeastern Brazil against Alzheimer's disease. Evidence-Based Complementary and Alternative Medicine, v. 2017, p. 1-7, 2017. Article ID 1753673. DOI: https://doi.org/10.1155/2017/1753673pt_br
dc.identifier.issn1741-4288
dc.identifier.urihttp://hdl.handle.net/123456789/885
dc.description.abstractAlzheimer’s disease (AD) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes. In the northeast region of Brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for AChE inhibition evaluation. The phenolic compounds content was determined by Folin–Ciocalteu test and flavonoid content with AlCl3 reagent using UV-visible spectrophotometry. The antioxidant activity was assessed analyzing the inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS) and by the β-carotene/linoleic acid system and acetylcholinesterase inhibition using qualitative and quantitative tests. The combination of better acetylcholinesterase inhibitory and antioxidant activities pointed out six species, in descending order, as the best potential sources of therapeutic agents against AD: Hancornia speciosa > Myracrodruon urundeuva > Copaifera langsdorffii > Stryphnodendron coriaceum > Psidium guajava > Mangifera indica. Besides, the phenolic compounds in the species probably contribute to these activities. However, further pharmacological studies to assess the specific applications of these plants against AD are required to confirm these results.pt_br
dc.description.sponsorshipFAPEMA; CNPqpt_br
dc.language.isoenpt_br
dc.publisherHINDAWIpt_br
dc.subjectAlzheimer’s diseasept_br
dc.titleMedicinal Plants from Northeastern Brazil against Alzheimer’s Diseasept_br
dc.typeArticlept_br
Aparece nas coleções:Artigos - Enfermagem (CCSST)
Artigos - Engenharia de Alimentos

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