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dc.contributor.authorANDRADE-NETO, Valter F. de-
dc.contributor.authorSILVA, Tito da-
dc.contributor.authorLOPES, Lucia M. X.-
dc.contributor.authorROSÁRIO, Virgílio E. do-
dc.contributor.authorVAROTTI, Fernando de Pilla-
dc.contributor.authorkrettli, Antoniana U.-
dc.date.accessioned2018-05-04T19:50:27Z-
dc.date.available2018-05-04T19:50:27Z-
dc.date.issued2007-
dc.identifier.citationANDRADE NETO, V. F. et al. Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis. Antimicrobial Agents and Chemotherapy, v. 51, p. 2347-2350, 2007. DOI: 10.1128/AAC.01344-06.pt_br
dc.identifier.issn0066-4804-
dc.identifier.urihttp://hdl.handle.net/123456789/900-
dc.description.abstractExtracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7'R,8S,8'S)-3',4'-methylenedioxy-4,5-dimethoxy-2,7'-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of < or =0.32 microM. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.pt_br
dc.language.isoenpt_br
dc.publisherAmerican Society for Microbiologypt_br
dc.subjectAntiplasmodial activitypt_br
dc.subjectLignanaspt_br
dc.subjectPlasmodiumpt_br
dc.titleAntiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformispt_br
dc.title.alternativeAtividade Antiplasmodial de Lignanas Ariltetralona de Holostylis reniformispt_br
dc.typeArticlept_br
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