Please use this identifier to cite or link to this item: https://repositorio.ufma.br/jspui/handle/123456789/900
Title: Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis
Other Titles: Atividade Antiplasmodial de Lignanas Ariltetralona de Holostylis reniformis
Authors: ANDRADE-NETO, Valter F. de
SILVA, Tito da
LOPES, Lucia M. X.
ROSÁRIO, Virgílio E. do
VAROTTI, Fernando de Pilla
krettli, Antoniana U.
Keywords: Antiplasmodial activity
Lignanas
Plasmodium
Issue Date: 2007
Publisher: American Society for Microbiology
Citation: ANDRADE NETO, V. F. et al. Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis. Antimicrobial Agents and Chemotherapy, v. 51, p. 2347-2350, 2007. DOI: 10.1128/AAC.01344-06.
Abstract: Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7'R,8S,8'S)-3',4'-methylenedioxy-4,5-dimethoxy-2,7'-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of < or =0.32 microM. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.
URI: http://hdl.handle.net/123456789/900
ISSN: 0066-4804
Appears in Collections:Artigos - Engenharia de Alimentos

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