Use este identificador para citar ou linkar para este item: https://repositorio.ufma.br/jspui/handle/123456789/886
Título: Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease
Autor(es): PENIDO, Alexandre Batista
MORAIS, Selene Maia de
RIBEIRO, Alan Bezerra
ALVES, Daniela Ribeiro
RODRIGUES, Ana Livya Moreira
SANTOS, Leonardo Hunaldo dos
MENEZES, Jane Eire Silva Alencar de
Palavras-chave: Alzheimer’s disease
Data do documento: 2017
Editor: HINDAWI
Citação: PENIDO, A. B. et al. Medicinal plants from Northeastern Brazil against Alzheimer's disease. Evidence-Based Complementary and Alternative Medicine, v. 2017, p. 1-7, 2017. Article ID 1753673. DOI: https://doi.org/10.1155/2017/1753673
Resumo: Alzheimer’s disease (AD) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes. In the northeast region of Brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for AChE inhibition evaluation. The phenolic compounds content was determined by Folin–Ciocalteu test and flavonoid content with AlCl3 reagent using UV-visible spectrophotometry. The antioxidant activity was assessed analyzing the inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS) and by the β-carotene/linoleic acid system and acetylcholinesterase inhibition using qualitative and quantitative tests. The combination of better acetylcholinesterase inhibitory and antioxidant activities pointed out six species, in descending order, as the best potential sources of therapeutic agents against AD: Hancornia speciosa > Myracrodruon urundeuva > Copaifera langsdorffii > Stryphnodendron coriaceum > Psidium guajava > Mangifera indica. Besides, the phenolic compounds in the species probably contribute to these activities. However, further pharmacological studies to assess the specific applications of these plants against AD are required to confirm these results.
URI: http://hdl.handle.net/123456789/886
ISSN: 1741-4288
Aparece nas coleções:Artigos - Ciências Naturais/Biologia (CCSST)
Artigos - Enfermagem (CCSST)

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